What Hartmut mentions is not the hard part, button/switch presses can be automatized. But what is more annoying is that MAME expects a full restart when loading a cartridge. I don't know if it's doable to automatically switch to Morphy.

It's also the reason Chessmaster Diamond PM10/PM11 don't work correctly on MAME (maybe you found a way to work around that in CB-EMu)